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Dr Mark Herzberg – Calprotectin – From Natural Antimicrobial to Anti-tumour Therapeutic?

Dr Mark Herzberg – Calprotectin – From Natural Antimicrobial to Anti-tumour Therapeutic?

Calgranulins are relatively small proteins, usually around 100 amino acids long. Calprotectin is a complex of two of these small proteins, S100A8 and S100A9, getting its name from its protective, antimicrobial properties. Dr Mark Herzberg at the University of Minnesota, USA, has extensively researched the antimicrobial action of this protein complex, and this knowledge is now leading serendipitously to the development of potential therapeutic agents for certain types of human cancer.

Dr Rakesh S. Chandran – Sustainable Weed Coexistence in Corn Crops

Dr Rakesh S. Chandran – Sustainable Weed Coexistence in Corn Crops

Agricultural weeds have the potential to cause significant crop loss. As such, conventional weed management practices have aimed to keep crop fields free from weeds through the broad application of herbicides. However, these practices have damaging consequences on the surrounding environment. Dr Rakesh Chandran and his team in the Agriculture and Natural Resources Department of West Virginia University have developed a more sustainable herbicide application regime that allows weeds to coexist with corn crops at acceptable levels, with the aim of improving environmental health without significantly sacrificing crop yield.

Dr Shikha Nangia – The Blood-Brain Barrier: More than Just a Barrier

Dr Shikha Nangia – The Blood-Brain Barrier: More than Just a Barrier

Neurodegenerative disorders present a major cause of death and disability worldwide. Treatments are typically expensive, non-efficient, and invasive. Although scientists are committed to finding better treatment strategies, the challenge of penetrating the blood-brain barrier remains. This highly selective envelope protects our brain from harmful substances but also prevents drugs from reaching the brain when needed. Dr Shikha Nangia at Syracuse University, USA, focuses on understanding the molecular structure of this complex interface to ultimately facilitate the transport of drugs across the blood-brain barrier.

Dr Shannon Westlake | Dr Kevin Hunt – Human Elements of Pollinator Conservation

Dr Shannon Westlake | Dr Kevin Hunt – Human Elements of Pollinator Conservation

The alarming decline of pollinating insects in recent years has garnered a wave of interest from the media, scientists and the public. This has resulted in a wealth of research into pollinator conservation, but despite this, adoption of beneficial practices that support pollinators has been low amongst private landholders. Dr Shannon Westlake and Dr Kevin Hunt of Mississippi State University have been investigating the human elements behind pollinator conservation, with the aim of developing targeted outreach and support programs to improve the uptake of conservation efforts amongst landholders.

Dr Juliana Bowles – Computing Conflict-free Treatments for Multiple Chronic Illnesses

Dr Juliana Bowles – Computing Conflict-free Treatments for Multiple Chronic Illnesses

Modern treatments for patients with more than one chronic condition can be highly precarious, and in many cases, simultaneous treatments for different illnesses can be detrimental to each other and ultimately, the patient. Dr Juliana Bowles at the University of St Andrews believes that this pressing issue can be solved with the help of advanced computational techniques. Her team has explored the ability of such techniques to calculate reliable outcomes within models of complex systems. Their work promises to significantly enhance the ways in which treatments for chronic conditions could be delivered – improving safety and quality of life for patients.

Dr Madhumita Chatterjee | Professor Michael Lämmerhofer | Professor Tilman Schäffer – Platelet Lipidomics: A Novel Approach to Assessing Cardiovascular Risk

Dr Madhumita Chatterjee | Professor Michael Lämmerhofer | Professor Tilman Schäffer – Platelet Lipidomics: A Novel Approach to Assessing Cardiovascular Risk

Cardiovascular disease (CVD) is the world’s leading cause of preventable death. A multidisciplinary team of researchers, Dr Madhumita Chatterjee (University Hospital Tübingen), Professor Michael Lämmerhofer and Professor Tilman Schäffer (both engaged with the University of Tübingen) are investigating the previously unrecognised molecular mechanisms that direct the function of tiny blood cells known as platelets in the formation of blood clots or thrombi, a condition that contributes to thrombosis and atherosclerosis. Their work is leading to the development of a new diagnostic tool to determine the risk of thrombosis in patients with CVD and also suggest potential therapeutic strategies to prevent such complications.

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Scientia Issue #129

Scientia Issue #129

  ACHIEVING AGRICULTURAL SUSTAINABILITY THROUGH INNOVATION   This critical issue of Scientia celebrates scientists who tackle one of the greatest challenges of our time: ensuring global food security and agricultural sustainability into the future....

Scientia Issue #128

Scientia Issue #128

IMPROVING HEALTH ACROSS THE GLOBE: INNOVATIONS FOR A NEW DECADE We open 2020 and this critical issue of Scientia by celebrating a diverse range of scientific breakthroughs and achievements that are driving forward health and well-being worldwide. In this new...

Scientia Issue #127

Scientia Issue #127

  STRENGTHENING THE STEM COMMUNITY THROUGH INCLUSIVE EDUCATION   In this critical issue of Scientia, we showcase an inspiring array of projects, each seeking to enhance science, technology, engineering and mathematics (STEM) education worldwide....

Editor’s Pick

Dr Mark Herzberg – Calprotectin – From Natural Antimicrobial to Anti-tumour Therapeutic?

Dr Mark Herzberg – Calprotectin – From Natural Antimicrobial to Anti-tumour Therapeutic?

Calgranulins are relatively small proteins, usually around 100 amino acids long. Calprotectin is a complex of two of these small proteins, S100A8 and S100A9, getting its name from its protective, antimicrobial properties. Dr Mark Herzberg at the University of Minnesota, USA, has extensively researched the antimicrobial action of this protein complex, and this knowledge is now leading serendipitously to the development of potential therapeutic agents for certain types of human cancer.

Dr Madhumita Chatterjee | Professor Michael Lämmerhofer | Professor Tilman Schäffer – Platelet Lipidomics: A Novel Approach to Assessing Cardiovascular Risk

Dr Madhumita Chatterjee | Professor Michael Lämmerhofer | Professor Tilman Schäffer – Platelet Lipidomics: A Novel Approach to Assessing Cardiovascular Risk

Cardiovascular disease (CVD) is the world’s leading cause of preventable death. A multidisciplinary team of researchers, Dr Madhumita Chatterjee (University Hospital Tübingen), Professor Michael Lämmerhofer and Professor Tilman Schäffer (both engaged with the University of Tübingen) are investigating the previously unrecognised molecular mechanisms that direct the function of tiny blood cells known as platelets in the formation of blood clots or thrombi, a condition that contributes to thrombosis and atherosclerosis. Their work is leading to the development of a new diagnostic tool to determine the risk of thrombosis in patients with CVD and also suggest potential therapeutic strategies to prevent such complications.

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The importance of connecting science and society – a writer’s view

The importance of connecting science and society – a writer’s view

Breaking down the barriers between scientists and the public is becoming increasingly important. With the recent COVID-19 pandemic sweeping the globe, it is more apparent than ever how important accessible and accurate scientific information is to society. Because these global problems often require scientific solutions, such as the development of new vaccines, the public should have the opportunity to engage if they choose to.

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Here, #writer & #scientist @KelleighGreene discusses the importance of accurate&accessible #scicomm. She explains why good scicomm is especially crucial during global crises, such as the #COVID19 #pandemic, & shares her experience of writing for #Scientia: https://t.co/nq3uDE8RoR

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Here, #writer & #scientist @KelleighGreene discusses the importance of accurate&accessible #scicomm. She explains why good scicomm is especially crucial during global crises, such as the #COVID19 #pandemic, & shares her experience of writing for #Scientia: https://t.co/nq3uDE8RoR

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