Health and Medicine
Maternal Diabetes and Adult Morbidity in the Offspring: The Team Study at Cincinnati Children’s Hospital Medical Center
While most people are aware of the health complications associated with diabetes, the impact of maternal diabetes on their children later in life is less understood. A research group at Cincinnati Children’s Hospital Medical Center (Ohio, USA) led by Dr Jane Khoury is working to change this. Their ongoing study, ‘Level and timing of diabetic hyperglycaemia in utero: The transgenerational effect on adult morbidity’ (TEAM study) is driving forward our understanding of the effects of maternal diabetes during pregnancy, to improve healthcare provision for both mothers and their children.
The Children and Young People’s Mental Health Coalition (CYPMHC) brings together more than 200 leading charities in the UK with the shared goal of improving the mental health and well-being of children and young people. In this exclusive interview, we speak with Oliver Glick, Policy Officer at CYPMHC, to hear about their achievements over the past decade and future plans.
The Malaysian Psychological Association was established in 1988 to promote the field of psychology in the country. In this exclusive interview, we speak with Associate Professor Dr Rozainee Khairudin, President of the Malaysian Psychological Association, to hear about their critical work in developing psychology, which during the global COVID-19 pandemic, is more important than ever.
Professor Carl Borrebaeck | Dr Ulrika Axelsson – Finding the Molecular Fingerprint of Psychological Resilience in Breast Cancer Patients
Professor Carl Borrebaeck and Dr Ulrika Axelsson are Director and Deputy Director, respectively, of the CREATE Health Translational Cancer Centre, Lund University, Sweden; a venue with an outstanding record of world-class cancer research. They are leading research into the fascinating topic of whether cancer patients’ psychological resilience after their cancer diagnosis may be linked to biomolecular processes, suggesting a mind-body link between the ability to cope psychologically and its impact on cancer prognosis.
The potential health risks of tattooing are known. However, many of the regulations which govern the practice of tattooing are somewhat relaxed compared to other industries. Dr Christopher Hohl and the Chromatography Section at the State Laboratory Basel-City, Switzerland, work to analyse the composition of tattoo inks and investigate the effects of tattooing to provide the authorities with the evidence needed to improve tattoo safety standards.
‘Our audacious idea is to cure cancer.’ Dr Kenneth Pienta at the Johns Hopkins School of Medicine, USA, speaks with genuine passion about his ground-breaking research. With his team, he has recently discovered that in every type of cancer, a special type of rare cancer cell – a polyaneuploid cancer cell (PACC) – exists and hides within the greater cancer cell population. The team hypothesises that ‘PACCs are a master mediator of therapy tolerance’ and thus, the critical treatment target. Now, in a call to arms, Dr Pienta is asking researchers and scientists across diverse disciplines to unite in developing a cure for cancer.
Poor sleep is a common difficulty issue for teenagers and young adults worldwide. Unfortunately, the impact of poor sleep is substantial with clear links to mental health difficulties. Dr Colleen Carney, an Associate Professor and the Director of the Sleep and Depression Laboratory at Ryerson University, Canada, is committed to helping people sleep better. Dr Carney has recently turned her expertise to the development of an innovative app to alleviate sleep problems in teenagers and young adults.
Haematopoiesis is the process through which cellular blood components are produced. It starts during embryonic development to ensure the production of blood cells such as erythrocytes (red cells), leukocytes (white cells), and platelets and continues throughout our lives. All blood cells derive from haematopoietic stem cells located in the bone marrow and, unfortunately, blood cancers may occur during this process. Whether blood cells become inefficient or grow excessively, the outcomes are usually devastating. Dr Chen Zhao (University of Iowa) and Dr Qianze Dong (China Medical University) are exploring the cellular mechanisms of haematopoietic stem cells.
Cancer is one of the most common causes of mortality worldwide and diagnosis rates are continually increasing. An estimated one in three women and one in two men will be diagnosed with a form of cancer at some point throughout our lives. For many cancer types, chemotherapy and radiotherapy are the chosen treatment methods, but their success rates are surprisingly limited, and both can cause serious side-effects. Dr Afsaneh Lavasanifar and her research group at the University of Alberta have set out to develop drug-delivery systems to improve the effectiveness of cancer treatment and reduce side-effects. Their research involves the targeted delivery of drug-loaded nanoparticles directly to tumour tissues.
Professor Sara Brucker | Professor Olaf Riess | Professor Oliver Kohlbacher – Mayer-Rokitansky-Küster-Hauser Syndrome: Interrogation of Genetic Pathology and Novel Surgical Intervention Methods
In otherwise phenotypical normal females, that is, females with normal ovaries and regular hormone production, Type I Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome results in the absence of the uterus (womb) and the upper two-thirds of the vagina. Type II MRKH syndrome presents with the same utero-vaginal malformation but also further difficulties that can include structural issues within the urological and skeletal systems. Professors Sara Brucker, Olaf Riess, and Oliver Kohlbacher from the University of Tuebingen are elucidating the molecular pathology of the disorder and have developed a surgical intervention to overcome the major life-changing aspects of this condition.
It is undoubtable that virtual reality and augmented reality will soon be an integral part of our daily lives at home, in education, and at work. Here, we look at some of the exciting projects that Dr William Hurst of the Department of Computer Science at Liverpool John Moores University is driving forward and read how he is embracing virtual reality and augmented reality to enhance teaching and education, providing insight into how such technology may be utilised in the not too distant future.
The immune response entails the rapid activation of the immune cells to ensure effective defence from pathogens through the inflammatory pathway, as well as maintain immune homeostasis through the anti-inflammatory pathway. Immune cell activation happens as the result of rapid and severe changes in the expression of the immune-response genes. These depend on regulatory mechanisms controlling the processes of transcription, translation, and modification of these genes to produce functional proteins. Dr Elke Glasmacher, Head of Immune and Cell Biology at Roche, researches the important molecular mechanisms underlying how cells are activated or repressed.
Calgranulins are relatively small proteins, usually around 100 amino acids long. Calprotectin is a complex of two of these small proteins, S100A8 and S100A9, getting its name from its protective, antimicrobial properties. Dr Mark Herzberg at the University of Minnesota, USA, has extensively researched the antimicrobial action of this protein complex, and this knowledge is now leading serendipitously to the development of potential therapeutic agents for certain types of human cancer.
Neurodegenerative disorders present a major cause of death and disability worldwide. Treatments are typically expensive, non-efficient, and invasive. Although scientists are committed to finding better treatment strategies, the challenge of penetrating the blood-brain barrier remains. This highly selective envelope protects our brain from harmful substances but also prevents drugs from reaching the brain when needed. Dr Shikha Nangia at Syracuse University, USA, focuses on understanding the molecular structure of this complex interface to ultimately facilitate the transport of drugs across the blood-brain barrier.
Modern treatments for patients with more than one chronic condition can be highly precarious, and in many cases, simultaneous treatments for different illnesses can be detrimental to each other and ultimately, the patient. Dr Juliana Bowles at the University of St Andrews believes that this pressing issue can be solved with the help of advanced computational techniques. Her team has explored the ability of such techniques to calculate reliable outcomes within models of complex systems. Their work promises to significantly enhance the ways in which treatments for chronic conditions could be delivered – improving safety and quality of life for patients.
Dr Madhumita Chatterjee | Professor Michael Lämmerhofer | Professor Tilman Schäffer – Platelet Lipidomics: A Novel Approach to Assessing Cardiovascular Risk
Cardiovascular disease (CVD) is the world’s leading cause of preventable death. A multidisciplinary team of researchers, Dr Madhumita Chatterjee (University Hospital Tübingen), Professor Michael Lämmerhofer and Professor Tilman Schäffer (both engaged with the University of Tübingen) are investigating the previously unrecognised molecular mechanisms that direct the function of tiny blood cells known as platelets in the formation of blood clots or thrombi, a condition that contributes to thrombosis and atherosclerosis. Their work is leading to the development of a new diagnostic tool to determine the risk of thrombosis in patients with CVD and also suggest potential therapeutic strategies to prevent such complications.
Plant pathogens transmitted by insect vectors can have devastating consequences for farmers across the globe. Huanglongbing disease of citrus trees and zebra chip disease of potatoes are both caused by bacteria transmitted by specific psyllid insect species, and have the potential to destroy entire crops, causing enormous economic losses. Conventional control methods rely on pesticides, but these can have adverse effects on the environment. In addition, resistance to these chemicals is on the rise in many pest species. Dr Bryce Falk and his plant pathology team at the University of California, Davis aim to solve this problem by developing highly targeted psyllid control methods using virus-based gene technologies.
There is a strong body of evidence from animal and human studies showing that the acidic external microenvironment (local environment) of cells associated with tumours plays a significant role in the progression and migration of cancers. Indeed, in a rat model, systemic buffering which reduces acidic pH levels also reduces both cancer progression and drug resistance. Dr Hiromi Wada at the Japanese Society of Inflammation and Metabolism in Cancer and his colleagues are investigating the effect of an alkaline diet on the tumour microenvironment, and its potential to enhance the efficacy of anti-cancer treatments.
The mechanisms that control the transcription of DNA to produce RNA and the building blocks of life, proteins, are a fundamental cellular process in all living organisms. Dr Andreas Mayer at the Max Planck Institute for Molecular Genetics in Germany has spent more than a decade unravelling these complex processes. Using newly developed high-resolution genome-wide techniques, his team is discovering the vital role that RNA polymerase II transcription plays in stem cell differentiation, where a cell changes from one cell type to another usually to perform a more specialist function.
Dr Jennifer Kay | Professor Bevin Page Engelward – The MIT Superfund Research Program: Studies on Cleaning Up Genes and the Environment
In the United States, there are thousands of industrial sites contaminated by the irresponsible disposal of chemical waste. The higher than expected frequency of cancer cases near these sites has caused alarm, since many of the chemical contaminants found at these sites have been linked to the development of long-term health problems, including cancer. As leaders of the Massachusetts Institute of Technology Superfund Research Program, Dr Jennifer Kay (Research Scientist and Research Translation Director) and Professor Bevin Page Engelward (Program Director) are using their expertise to investigate the genetic factors that influence susceptibility to adverse health outcomes following exposure to environmental chemicals.
Professor Steven E. Wilson – Clearing the Haze: Understanding the Process of Scarring Following Corneal Injury
Any injury such as trauma, surgery or infection to the cornea in the eye may result in persistent scarring (clinically referred to as fibrosis) due to the wound healing response. Professor Steven E. Wilson at the Cole Eye Institute of the Cleveland Clinic Foundation has identified that defective epithelial basement membrane (EBM) regeneration plays a central role in the development of scar producing myofibroblast cells. Critically, Professor Wilson suggests that the pathophysiological consequences of defective EBM regeneration are also likely to have wider relevance to the fibrosis that occurs in other organs, such as the lungs, heart, kidneys, and skin.
We all know exercise is good for us. In addition to the renowned physical benefits, Professor Kirk Erickson in the Department of Psychology at the University of Pittsburgh is providing powerful evidence that exercise may improve cognitive faculties throughout the lifespan. Read on to discover the wide range of ways in which exercise can help us to live our lives to the fullest across the years, and how the emerging field of health neuroscience may inform public health policy for our better good.
Dr Jun Hua, Associate Professor at the F. M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute and Johns Hopkins University, USA, leads a team focused on developing novel magnetic resonance imaging (MRI) technologies for imaging the structure and function of the brain. Recently, they have been pioneering the development of new MRI techniques that can be used to improve pre-surgical planning for neurological patients and optimise patient outcomes.
Professor Stephan Pleschka | Professor M Lienhard Schmitz – The Influenza A Genotype and Cell Signalling Networks
Influenza viruses pose a major threat despite advances in vaccine and drug development. Research into the cellular and molecular mechanisms that drive influenza viruses aims to reveal new drug targets to fight disease. However, information on the molecular mechanisms of how influenza viruses infect and replicate in host cells is currently limited. As part of the German Collaborative Research Centre 1021 (CRC1021), Professors Stephan Pleschka and M Lienhard Schmitz at the Justus Liebig University Giessen in Germany are exploring the impact of the genetic variability of influenza viruses on the interactions between the virus and host cell that regulate viral infection and replication.
It is estimated that in the USA alone, over 2.7 million individuals require a wheelchair for mobility. By far the greatest fraction of manual wheelchair users rely on conventional manual pushrim drive wheelchairs, yet the use of such wheelchairs leads to well-documented shoulder injuries and chronic pain. We read here of how Steve Green of Green Technologies, Inc, is tackling this problem through the development and patenting of a wheelchair anti-rollback device that addresses these injury and safety issues with an innovative yet simple mechanism.
Despite dramatic advances in neuroscience and biology in the 20th and 21st centuries, our understanding of the brain remains very limited. Dr Yan M Yufik, Head at Virtual Structures Research Inc, USA, is a physicist and cognitive scientist who has spent over 20 years combining experimental findings and theoretical concepts in domains as diverse as neuroscience and thermodynamics to form a theory of the brain. His focus has been on elucidating the mechanisms underlying human understanding and applying the results to the design of machines that can not only learn but understand what they are learning.
Legionella bacteria are known to cause Legionnaire’s disease, a potentially severe and lethal form of pneumonia. The bacteria can be classified into different serogroups forming specific sub-types of L. pneumophila. In humans, serogroup 1 is the most common cause of pneumonia, being responsible for approximately 80% of all cases. However, the other subgroups can also cause pneumonia, resulting in a range of outcomes from mild to severe, and these are more difficult to accurately detect. Dr Akihiro Ito at Kurashiki Central Hospital, Japan, is advancing the detection of all forms of L. pneumophila to facilitate more timely healthcare interventions for Legionnaires’ disease.
Type 2 diabetes (T2D) is among the most impactful and costly biomedical challenges confronting society. Current treatment regimens for T2D rely upon daily drug dosing and frequent glucose monitoring to normalise blood glucose levels. However, these medications can only delay disease progression and frequently have undesired side effects including hypoglycaemia and weight gain. Growing evidence supports a key role for the brain in glucose homeostasis and diabetes pathogenesis. Dr Jarrad Scarlett and his research team at the University of Washington and Seattle Children’s Hospital are working on the development of novel pharmaceuticals to target the brain to induce sustained remission of T2D.
Dr Amy Schmidt – iAMResponsibleTM: Educating Food Producers & Consumers About Antimicrobial Resistance
Antimicrobial resistance (AMR), the acquired ability of microorganisms to withstand the effects of medications used to treat them, is a serious and growing threat to public health. In collaboration with experts from various US institutions, Dr Amy Schmidt at the University of Nebraska-Lincoln has developed a program called the iAMResponsibleTM Project, aimed at educating consumers, agricultural producers and others on the risks associated with AMR, as well as strategies to mitigate these risks.
Accidental falls are one of the leading causes of injuries and accidental death for the elderly, and the risk of falling increases significantly in those with neurological disorders or frailty. Dr Fay B Horak and her colleagues at Oregon Health & Science University and APDM Wearable Technologies, USA, are investigating the use of APDM’s novel wearable technology to monitor mobility in daily life of individuals at risk of falling to help prevent falls and identify prefrail elderly individuals.