Medical conditions that affect the brain can have severe impacts on people’s lives. Many of these conditions can be difficult to treat, including epilepsy which affects the brain to cause seizures and the common form of dementia known as Alzheimer’s disease. Dr Arun Swaminathan at the University of Nebraska Medical Center specialises in the treatment of epilepsy. He also collaborates with fellow researchers to explore treatment options for Alzheimer’s disease.
Applying mathematics to biology can help reveal the elusive details of life. Professor Wilfred D. Stein and his colleagues from the Hebrew University of Jerusalem and institutes worldwide have used quantitative tools to tackle topics ranging from cancer treatment to drug-resistant malaria, and lately, the evolution of the human genome. His extensive and broad work has supported scientists in many different areas of biomedicine and will leave a lasting impact on life science.
Dr Richard B. Brandon | Dr Thomas D. Yager – A Fully Integrated Diagnostic Test to Discriminate Sepsis from Infection-negative Systemic Inflammation
Sepsis is a serious medical condition that manifests with a dysregulated immune response to an infection in the bloodstream, and is a major cause of morbidity and mortality worldwide. Many non-infectious conditions can lead to a state of hyper-inflammation known as the systemic inflammatory response syndrome (SIRS), which clinically can look very similar to sepsis. A lack of analytical tools that allow for the early detection of sepsis makes discrimination between sepsis and SIRS a very complex but critical diagnostic task. Dr Richard B. Brandon, Dr Thomas D. Yager and their colleagues at Immunexpress have developed a molecular diagnostic platform capable of detecting genetic biomarkers diagnostic for sepsis in about an hour. Early sepsis diagnosis can potentially lead to better patient management, more efficient use of resources, and a more sensible approach to the use of antibiotics.
Healthcare systems around the world are under increasing pressure as a result of depleting resources accompanied by rising demands. Dr Johannes Bircher’s reflections on the inherent failings of modern healthcare systems have coalesced into an important proposal for a new concept of health, known as the Meikirch model. Here, we look at the potential of the Meikirch model to drive forward a critical paradigm shift in healthcare delivery.
Dr Yasuhiro Sakai | Dr Kazuhiko Kuwahara – GANP: An Immunoactive Protein with a Key Role in Tumourigenesis
Investigating the role of an immune system protein, GANP, and its coding gene, ganp, Dr Yasuhiro Sakai and Dr Kazuhiko Kuwahara (Fujita Health University School of Medicine) have unveiled a potential role for this important protein in tumourigenesis. The scientists apply a multidisciplinary approach to identify potential therapeutic solutions to aid cancer prognosis, a collaboration that occurs in the emerging field of immunopathology. The researchers focus on the differential levels of GANP which appear to correlate with breast cancers (low GANP) and with lymphocytic cancers (high GANP).
The rise of pandemic-causing viruses is a worrying development arising as a by-product of our hugely connected world, and scientists must forge new paths to tackle these diseases. With researchers like Dr Babita Agrawal from the University of Alberta at the helm, we can hope to enter a new era of preventatives and therapeutics to help us fight disease. Dr Agrawal and her team are investigating novel vaccines and immunotherapeutics for influenza, Hepatitis C, tuberculosis, and even cancer.
Ubiquitin is a polypeptide that is tagged on to various proteins to signal a range of biological processes. The alteration of the ubiquitin system plays a pivotal role in the pathogenesis of diseases including autoimmune disorders and cancer. The process of ubiquitinylation involves a cascade of enzymes, E1, the activating enzyme, E2 (conjugating enzymes) and E3 (ligases). Characterisation of the ubiquitinylation process of key proteins that impact stems cells, immune cells, and cancers is vital to identify therapeutic targets which may influence the progression of autoimmune conditions and cancers. The ubiquitin system is compromised in the majority of cancers and is the focus of research by Dr Yi Sheng of York University, Canada.
Brain tumours and other central nervous system diseases can be exceptionally difficult to treat. This is often due to the blood-brain barrier which can pose a significant obstacle when trying to get drugs to their intended site of action. Dr Sean Lawler and his team from Brigham and Women’s Hospital, Harvard Medical School are aiming to bridge the gap between laboratory research and clinical treatment in their quest to find new ways to effectively deliver therapies to the brain and treat challenging diseases, especially the lethal brain tumour glioblastoma.
Multidrug resistance is one of the main culprits underlying the failure of chemotherapy as a cancer treatment. Whilst many therapies are initially effective, a considerable proportion of patients eventually incur a poor prognosis and recurrence of malignant spread due to developing drug resistance at a later stage. Dr Rock J. Mancini, from Washington State University, has devised an approach that exploits proteins over-expressed in drug-resistant cancers to convert inactive prodrug substrates into active drugs that initiate an immune response targeted at cancer cells.
Since the turn of the century, a myriad of exciting applications for graphene have emerged. Amongst the most exciting might be its use as a scaffold for promoting tissue growth in the treatment of various medical conditions, including osteoarthritis. Researchers at Boise State University in the USA and Carl von Ossietzky University of Oldenburg in Germany are gaining a greater understanding of the interactions between graphene and cells, towards the development of implantable graphene-based devices that can rebuild damaged tissue.
UK Biobank is a large-scale biomedical database and research resource containing genetic, lifestyle and health information from half a million UK participants. The database, which is regularly augmented with additional data, is globally accessible to approved researchers and scientists undertaking vital research into the most common and life-threatening diseases. UK Biobank’s research resource is a major contributor to the advancement of modern medicine and treatment and has enabled several scientific discoveries that improve human health. In this exclusive interview, we speak with Professor Sir Rory Collins FMedSci FRS, Principal Investigator and Chief Executive of UK Biobank, to hear about the achievements to date and the ambitious and unique potential of this exciting project.
Enzymes make life as we know it possible. These active proteins are vital in nutrient cycling, metabolism, and cell functioning. With their diverse range of functions and ubiquity, enzymes could offer techniques to support healthy agricultural ecosystems, and as such, improve sustainability and future food security. Understanding their activities is vital to the organic agriculture revolution. Dr Zachary Senwo and his team at Alabama Agricultural and Mechanical (A&M) University have contributed years of important research to uncover the potential of enzymes towards informing novel agricultural practices.
The effectiveness of cancer treatments could be hugely improved by a greater understanding of the cancer genome. This is the focus of the work of Dr John Paul Y.C. Shen, MD, of the University of Texas MD Anderson Cancer Center, who is creating comprehensive molecular ‘maps’ of cancer cells and their interactions. Understanding cancer at a molecular level is the first step towards Dr Shen’s very real hope of bringing personalised cancer treatments into the clinic.
Natural levels of biodiversity support healthy, resilient ecosystems, and thus also support valuable ecosystem services – such as providing clean water. However, pressures from climate change and habitat destruction are altering biodiversity across the globe. Understanding the mechanisms that give rise to biodiversity patterns is imperative to monitoring how it is changing and informing effective conservation strategies. Until recently, these mechanisms have been rarely explored and poorly understood. Dr Marta Jarzyna and her team at The Ohio State University are improving our understanding of biodiversity through extensive research, and developing novel modelling techniques.
It’s a long-held belief that a series of dams in the Snake River in Northwest USA constructed nearly 50 years ago has led to serious declines in Chinook salmon populations. However, new research by Dr David Welch and his team from Kintama Research Services Ltd shows that survival of Chinook salmon measured by a wide range of government agencies has fallen by 65% along the whole North American West Coast over this period. These results have significant implications for informing conservation strategies to protect and restore this important species.
The discovery of DNA has been one of the most important findings of the last century, yet there is still much more to uncover about the ‘additional chemical layer’ brought about by the chemical modification of amino acids and nucleotide bases. A large collaboration of researchers at institutions across Germany, known as SFB 1309, is led by Professor Thomas Carell at the Ludwig-Maximilians University in Munich. A key focus of SFB 1309 is to elucidate the details of the second layer of information beyond the sequence layer of biochemical molecules called Watson-Crick bases within our DNA.
Head and neck squamous cell carcinoma (HNSCC) constitutes around 90% of all head and neck cancers. Millions of individuals are diagnosed across the globe every year, very often too late and with poor prognosis. Among other factors, alcohol consumption and smoking increase the risk to develop HNSCC. Dr Muy-Teck Teh, from Queen Mary University of London, is driving forward our understanding of the factors leading to cancer, leading the development of novel less invasive detection methods, and progressing better therapeutic options.
Dr Patrick C. Still – Using Plants as a Source of Anti-Cancer Compounds for Undergraduate Research Experiences
Cancer, in all its forms, is one of the major causes of death across the world and we are in urgent need of more effective interventions for this global killer. Drugs used to treat diseases like cancer can be either synthetic in origin, semi-synthetic derivatives of natural products, or unmodified natural products.
Founded almost 50 years ago, the Association for Women in Science (AWIS) is a global network that inspires bold leadership, research, and solutions that advance women in STEM, spark innovation, promote organisational success, and drive systemic change. In this exclusive interview, we speak with AWIS president and world-renowned biomedical innovator Dr Susan Windham-Bannister, who describes the barriers that women face in the STEM workplace, and the many ways in which AWIS supports women in science and works towards eliminating inequality through systemic change.
First recognised over a century ago, the resistance of insects and other arthropods to pesticides is a growing problem, with implications for crop production and human health on a global scale. Dr David Mota-Sanchez and his team at Michigan State University are creating a worldwide, online database of resistance cases to catalogue the scale of the problem. Their work will aid decision makers in developing sustainable strategies to manage arthropod pests.
Huntington disease (HD) is an inherited and progressive neurological disorder which is currently fatal. Dr James E. Goldman and Dr Osama Al-Dalahmah, both at Columbia University, USA, are utilising new techniques in molecular biology to better understand the brain pathology associated with HD. Their vision is to develop therapeutics that can slow the progression of the disease, and ultimately, treat and even prevent it.
Ruptured and dissected aneurysms are medical emergencies that can have fatal consequences. There are two main surgical procedures to repair a ruptured aneurysm: open surgery and endovascular aneurysm repair. Unfortunately, both methods present a risk of developing spinal cord injury and paralysis. In addition, patients who develop paralysis after surgery have a significantly lower survival rate compared to non-paralysed patients. Dr. Hamdy Awad at The Ohio State University has spent most of his academic career focusing on the development of preclinical small and large animal models to understand the mechanisms of ischaemic spinal cord injury and discovery of novel therapeutics to prevent paralysis after aortic aneurysm surgery.
Nitric oxide is an ‘A-list’ celebrity amongst chemical compounds. Proclaimed ‘molecule of the year’ in 1992 by the American Association for the Advancement of Science, its physiological importance, discovered in 1985, was recognised in 1998 by the award of a Nobel prize to some of the researchers who had discovered its vital role in regulating blood vessels and blood pressure. Here we look at the pre-eminent work of Dr Alan N. Schechter at the National Institutes of Health in Bethesda, Maryland, USA, that is continuing to keep nitric oxide at the front and centre of groundbreaking biological research.
Differences in the prevalence and survival of male and female cancer patients have long been acknowledged but not well understood. Dr Josh Rubin (Departments of Paediatrics and Neuroscience at Washington University) and his collaborators have been the first to identify sex-specific differences in malignant transformation. This evidence will help to optimise sex-specific approaches to cancer treatment and contribute to the improvement of the outcomes and survival of cancer patients.
Climate change and environmental degradation are increasingly threatening our ability to feed a burgeoning human population. Switching to agricultural practices that support beneficial soil microbes, and thus healthy soils, may help farmers achieve the yields required for continued food security. Dr Zachary Senwo from the College of Agriculture, Life and Natural Sciences at Alabama A&M University has spent over two decades exploring how agricultural management practices impact soil health. In an extensive new project, his team is investigating soil nitrogen cycling and the role of microbes in soil health.
The eye movement disorders strabismus (characterised by eye misalignment) and nystagmus (characterised by involuntary oscillation of the eyes) together affect up to 5% of the population and have a detrimental impact on vision. These disorders also impact on facial appearance and social interaction, which may, in turn, lead to psychological difficulties. Dr Mary Whitman, at the Boston Children’s Hospital, USA, is working to understand the genetic causes and neurological mechanisms underlying eye movement disorders to improve treatment and, ultimately, prevent their onset.
Tropical forests and marine ecosystems in the Caribbean are biodiversity hotspots and home to many species found nowhere else on Earth. Increasing environmental stress from a changing climate, such as hurricanes, temperature rises and droughts, threaten to irreparably alter these precious systems. Coupled with ongoing pressures from human activities, some of these areas are especially at risk. Dr Jess Zimmerman and his colleagues at the University of Puerto Rico and throughout the US aim to provide the basis for predicting the future of these ecosystems, through their research at the Luquillo Experimental Forest in north-eastern Puerto Rico.
Genetically modified crops can offer a range of environmental and health benefits, such as reduced usage of chemical pesticides, improved farm efficiency and crop yields, and an enhanced nutritional profile. Despite this, fears surrounding genetic modification have led to a lack of acceptance of these foods by many consumers, regulators, and governmental organisations. Dr Richard Goodman from the Food Allergy Research and Resource Program at the University of Nebraska–Lincoln, is helping to shift the narrative around genetically modified crops, through his extensive work evaluating their safety.
Professor David Magnuson, at the University of Louisville, Kentucky, describes himself as ‘a CPG guy’ and occasionally, more informally as ‘a rat guy!’ His work on the function of the central pattern generator (CPG) in the rat spinal cord following spinal cord injury, has produced both surprising and thought-provoking results. This research may ultimately challenge the established clinical beliefs and practices around the ways to best rehabilitate human patients with severe spinal cord injury.
Professor Kim Dale | Dr Hedda Meijer – The Role of Notch Signalling within the Molecular Clock in the Early Development of the Skeleton
Cells possess the ability to interact with one another through complex signalling pathways. Different signals regulate how cells differentiate, undergoing modifications that ultimately allow them to adopt different cell fates and perform specific functions. The laboratory of Professor Kim Dale from the University of Dundee, Scotland, has made seminal contributions to our understanding of how the Notch signalling pathway controls the formation of tissues and organs in the earliest stages of development. Their important research has unveiled new insights into the molecular basis of Notch signalling in the context of normal development which will further our understanding of the molecular basis of developmental disorders and a multitude of diseases correlated with aberrant Notch signalling.
Pancreatic ductal adenocarcinoma (PDA) is an aggressive type of cancer. It is relatively common and is one of the leading causes of cancer mortality. Unfortunately, it is often detected only in the late stage of the disease and fails to respond to pre-surgical approaches, such as chemotherapy or radiotherapy, that are needed to shrink the tumour mass before surgical removal. Dr Scott Gerber at the University of Rochester Medical Center, USA, is working with colleagues to develop a novel combined therapy to overcome this issue and increase the survival of PDA patients.
Dr Elizabeth A. Cooper – New Sorghum Reference Genome Highlights Genetics Underlying Sweet Varieties
Sorghum is a staple crop in many regions of the world. As such, this versatile plant has been selectively bred into a number of cultivars, including sweet varieties predominantly used for forage, silage, sweet syrup and bioenergy production. Dr Elizabeth A. Cooper and her team at the University of North Carolina at Charlotte generated a full reference genome for the sweet sorghum cultivar ‘Rio’ with the aim of understanding the genetics underlying the differences between grain and sweet cultivars. Their research could provide a vital tool for biologists and breeders to improve sweet sorghum lineages.